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BMG LABTECH - NEPHELOstar |
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NEPHELOstar
Laser based light scatter measurement in microplates
The NEPHELOstar measures forward light scatter in microplates and offers the HTS/ Drug Screening laboratory an easy to use, low cost, and rapid method for checking the solubility of compounds. The flexibility and performance of the NEPHELOstar allows more applications to be adapted to nephelometry than ever before: - Drug solubility testing
- Bacterial and fungal growth
- Quality control
- Quantification of macromolecules (e.g. specific proteins)
- Formation of immunocomplexes to name but a few.
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NEPHELOstar
The NEPHELOstar microplate nephelometer detects particles in liquid samples by measuring forward scattered light when a laser beam is directed through the solution. This scattered light is detected at angles of up to 80 degrees, making it approximately thirty times more sensitive than tradional transmission readers that measure the reduction in direct light passing through a sample well.
Flexibily and performance of the NEPHELOstar allow more applications to be adaped to microplate-based laser nephelometry than ever before: - Automated drug solubility screening
- Microbial growth kinetics monitoring
- Precipitation and polymerization monitoring
The intensity and beam diameter of the laser light can be adjusted in the easy to use Software, and this allows measurement of light scatter in colored or turbid solutions. In addition, the flexible beam diameter allows measurement in 24, 48, 96 and 384-well microplate format.
These features, along with BMG LABTECH´s Digital Photon Integration (DPI) technology and a detection angle of 80°, ensure that the NEPHELOstar is approximately thirty times more sensitive than conventional transmission readers.
Temperature-regulated heating plates above and below the entire plate movement area provide uniform incubation up to 38°C.
Developed to meet high-throughput demands, this microplate-based nephelometer is faster than conventional solubility detection methods with the highest sensitivity and flexibility.
Self-monitoring laser diode
The light source is a red laser with a wavelength range of 635 nm. A laser diode has the advantage of higher stability than other light sources which gives better precision. The laser intensity can be adjusted via the software.
Variable laser beam width
An exclusive feature of the NEPHELOstar: the ability to adjust laser beam width. With a narrow beam width, liquid surface effects (meniscus effects) are minimized.
Reads 384-well plate formats
The NEPHELOstar is the only microplate nephelometer with the ability to read 384-well plates with excellent sensitivity. Use less sample and produce more data per plate.
Full-cone angle detection system
With the most advanced detection system, the NEPHELOstar can integrate the largest scattering angle, up to 80°. |
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